Prescription Medication Knowledge Base » Flovent 220 » My hospitalization and accolate

My hospitalization and accolate

Question:

This is a cryptographically signed message in MIME format. Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit I don’t understand your doctor’s comment on Accolate at all. In my case I was having fairly frequent episodes where walking 100′ was simply impossible and just getting out of bed and going to the bathroom did make me quite out of breath. Prednisone was the only thing that worked for me. Then *after* I started taking Accolate all of that went away completely. I have cats, I’m allergic to dust mites and molds as well. They don’t have much effect anymore. Cigarette smoke still does but it has to be really thick for that to happen. I’ve even had a sinus infection after that and it didn’t trigger the asthma at all. For me, Accolate provided the control that nothing else had. I still use Serevent once in a while (like on foggy days or when it rains) and I tend to use Albuterol before I exercise but I haven’t needed any rescue meds since I started the Accolate. I did use Flovent 220 while I had the sinus infection though. Basically since it was Accolate that gave me the control I have no idea what your doctor meant. You do have to be consistent about taking it though and it does take some time (it took me 3-4 months) to be fully effective. Loki – Hide quoted text — Show quoted text – Last week Wednesday I had to call 911 to take me to the hospital due to an asthma attack. I have had asthma for about 6 or so years and it has several triggers including animal dander (I have 4 cats and get my shots), dust, and mold. The night before I had cleaned out some cupboards in which water had leaked and I think I must have gotten a good breath of mold, since that night was uncomfortable for me and the following morning I had to turn back from the subway and return home to have my wife call 911. This was the first time that I had to be hospitalized although I have had a couple of bad attacks. The EMTs gave me two nebulized albuterols and then shipped me to the ER. There they gave me some more along with Salmeterol, magnesium, and other such. They also did a chest X-ray. When I didn’t clear quite as quickly or fully as they liked they suggested I be admitted. My peak flow at that point was 400 but I was still wheezing. I stayed overnight and got a perscription for a week of prednisone (4-2-2-1-1-1 ). When I contacted my Dr. he felt that they had been too cautious and if I could walk 100′, go to the bathroom by myself, all without getting out of breath, then I should not have been admitted. He also had asked why I had started with Accolate (my ussual "poison" is Aerobid and Seravent)? I had gotten on that after some questions with my Allergist and hoped that it might allow me to take less medication on a regular basis. Here is the kicker … My Dr. said that Accolate isn’t really for the sort of asthma control I wanted. That it was for keeping asthma from "exacerbating". He recommended I stop taking it, at least till a followup visit since it actually may have been partly responsible for my attack. I would be interested in anyone’s comment about the use of Accolate, my Dr.’s statements and anything else. The attack was QUITE frightening, the hospital stay was at the least dull, but at the same time agravating, if it was unecessary! "Americans, while occasionally willing to be serfs, have always been obstinate about being peasantry." F.Scott Fitzgerald

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Response:

Last week Wednesday I had to call 911 to take me to the hospital due to an asthma attack. I have had asthma for about 6 or so years and it has several triggers including animal dander (I have 4 cats and get my shots), dust, and mold. The night before I had cleaned out some cupboards in which water had leaked and I think I must have gotten a good breath of mold, since that night was uncomfortable for me and the following morning I had to turn back from the subway and return home to have my wife call 911. This was the first time that I had to be hospitalized although I have had a couple of bad attacks. The EMTs gave me two nebulized albuterols and then shipped me to the ER. There they gave me some more along with Salmeterol, magnesium, and other such. They also did a chest X-ray. When I didn’t clear quite as quickly or fully as they liked they suggested I be admitted. My peak flow at that point was 400 but I was still wheezing. I stayed overnight and got a perscription for a week of prednisone (4-2-2-1-1-1 ). When I contacted my Dr. he felt that they had been too cautious and if I could walk 100′, go to the bathroom by myself, all without getting out of breath, then I should not have been admitted. He also had asked why I had started with Accolate (my ussual "poison" is Aerobid and Seravent)? I had gotten on that after some questions with my Allergist and hoped that it might allow me to take less medication on a regular basis. Here is the kicker … My Dr. said that Accolate isn’t really for the sort of asthma control I wanted. That it was for keeping asthma from "exacerbating". He recommended I stop taking it, at least till a followup visit since it actually may have been partly responsible for my attack. I would be interested in anyone’s comment about the use of Accolate, my Dr.’s statements and anything else. The attack was QUITE frightening, the hospital stay was at the least dull, but at the same time agravating, if it was unecessary! "Americans, while occasionally willing to be serfs, have always been obstinate about being peasantry." F.Scott Fitzgerald

Response:

Author: admin on
Category: Flovent 220
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Prescription Medication Knowledge Base » Venlafaxine Effexor » EFFEXOR

EFFEXOR

Question:

Anyone have any experience with Effexor. I’ve tried Prozac, Paxil, Wellbutrin. None of them work well. Thanx!

See earlier comments. Effexor, although some people have good experiences with it, is not a first choice in treating PAD. Philip

Response:

Anyone have any experience with Effexor. I’ve tried Prozac, Paxil, Wellbutrin. None of them work well. Thanx! See earlier comments. Effexor, although some people have good experiences with it, is not a first choice in treating PAD. Philip

Hi…I have been on Effexor (was on) XR for a month. At first, it seemed to lift a bit of my depression and worry, but after, my anxiety became really bad. I seemed to become almost "hypo-manic", and my sleep was WORSE then it ever had been. I could fall asleep fairly easy, but would wake up VERY early, feeling really "hung-over". I really had alot of hope for this drug, but I guess everbody does <g. Well..back to the drawing board…. Peace… James

Response:

Anyone have any experience with Effexor. I’ve tried Prozac, Paxil, Wellbutrin. None of them work well. Thanx!

Response:

Anyone have any experience with Effexor. I’ve tried Prozac, Paxil, Wellbutrin. None of them work well. Thanx!

I was on venlafaxine (Effexor) for about 3 months. It worked great for my depression and pain, however the only side effect was sexual dysfunction, so I discontinued it for that reason. Can’t say it worked on any of my anxiety because I’m on clonazepam (Klonopin) for that, but I know it didn’t cause any increase in anxiety either. My dosage was 75 mg bid (twice daily). My dose of clonazepam is really low, almost subtherapeutic, 0.5 mg bid. Good Luck, Chris

Response:

hi all my doc suggested today that i go off clonazepam and start taking effexor as she is not happy with me being on clonazepam for indefinitely. i have tried many SSRI and was as sick as a dog and had anxiety like 24 hours a day for a long time. what has your experience of effexor been??? also how long does it take to taper off clonazepam??? thanks a lot kim

Does clonazepam work for you? If so, don’t switch meds but doctors. Effexor is not an SSRI but close enough. *If* you should decide to try Effexor do *not* stop clonazepam at the same time as you risk experiencing both Effexor initial side effects (including worsening of anxiety) and clomazepam withdrawal symptoms. Tapering off of clonazepam takes as long as it takes depending on how high the dose is and how you’ve been taking it. Diminishing the dose with one fourth or less every two weeks or so is a good pace as a rule but YMMV. But once again: if clonazepam works well, why fix something that isn’t broken? Philip – Hide quoted text — Show quoted text –

Response:

- Hide quoted text — Show quoted text – hi all my doc suggested today that i go off clonazepam and start taking effexor as she is not happy with me being on clonazepam for indefinitely. i have tried many SSRI and was as sick as a dog and had anxiety like 24 hours a day for a long time. what has your experience of effexor been??? also how long does it take to taper off clonazepam??? thanks a lot kim

ahhhhhhhhhhhhhh this is stoopid medicine your doc is a benzophobe and believes that effexor is less addictive or dependency causing then a benzo-it isn’t. It has to be weaned on and weaned off and is not less toxic a compound then clonazepam. If the Klonopin helps you then why tamper with what works-find another doc if possible effexor is a very good medication in more comprehensive in its ability then ssri’s similar to tca’s-in low doses it works well for loads of people-its main side effect is gastrointestinal and increased levels of anxiety similar to the ssri’s I wouldn’t hesitate to use it if it is indicated or in conjunction with klonopin if needed but your doc’s reasoning for using it is downright wrong LM

Response:

I was put on Effexor and it help me as far as the depression, I started on 150 mg and then my doc put me on Clonazepam (klonapin) .5 mg a day half in the morning and half at night. At the same time he increased my Effexor to 225 mg and to be honest I think the Klonapin is helping better because it takes care of my anxiety to a point and without anxiety I am not depressed…….lol I think Effexor works but I am going to talk my doc into lowering the effexor and increasing the klonapin…

– Hide quoted text — Show quoted text – For me it helped less with the panic/anxiety part. Had to supplement it with klonopin. It takes about 2-6 weeks to work. Less sexual side effects for me than paxil — "Oh dear, I think you’ll find reality’s on the blink again." — Marvin The Paranoid Android : hi everyone. I need your help . I was on PAXIL CR for a year for panic : attacks but had to be taken off of it cause it was raising my liver : enzyme level too high. So my doctor changed my medication to EFFEXOR. : Does anyone know anything about this medicine? Any bad side effects to : it? How long will it take for it to work? Well any information would be : helpful and much appreciated. Thanks so much. Tony : : : : : :

Response:

keep in mind that the two meds treat different symptoms of anxiety. the effexor is good for the obsessive worries, "rumination" as my therapist calls it. the nagging thoughts in the back of your head that won’t leave you alone. benzos don’t help much with those, but they relieve the physical symptoms, the fear, the dumping of adrenaline, etc. i think you have a good combo there (i’m on both as well). :-) -kelly

Response:

hi everyone. I need your help . I was on PAXIL CR for a year for panic attacks but had to be taken off of it cause it was raising my liver enzyme level too high. So my doctor changed my medication to EFFEXOR. Does anyone know anything about this medicine? Any bad side effects to it? How long will it take for it to work? Well any information would be helpful and much appreciated. Thanks so much. Tony

Response:

For me it helped less with the panic/anxiety part. Had to supplement it with klonopin. It takes about 2-6 weeks to work. Less sexual side effects for me than paxil — "Oh dear, I think you’ll find reality’s on the blink again." — Marvin The Paranoid Android

: hi everyone. I need your help . I was on PAXIL CR for a year for panic : attacks but had to be taken off of it cause it was raising my liver : enzyme level too high. So my doctor changed my medication to EFFEXOR. : Does anyone know anything about this medicine? Any bad side effects to : it? How long will it take for it to work? Well any information would be : helpful and much appreciated. Thanks so much. Tony : : : : : :

Response:

Author: admin on
Category: Venlafaxine Effexor
Tags: Venlafaxine Effexor

Prescription Medication Knowledge Base » Discontinue Use Of Zoloft In Lewy Body Caus » some tips on a Fender Deluxe Reverb

some tips on a Fender Deluxe Reverb

Question:

I’m looking to add a fender deluxe reverb to my arsenal. I need something that can be cranked but not wake the neighbors in the next county. My HR Deville 212 is too loud, but I have decided to hold on to it. The Fender DR, at 22 Watts fits the bill. What year should I look at (new, older, silver face etc) Thanks for the help. Derek

Response:

I’d say silver face on back to their creation.Thats just going by the articles I’ve read about them though

– Hide quoted text — Show quoted text – I’m looking to add a fender deluxe reverb to my arsenal. I need something that can be cranked but not wake the neighbors in the next county. My HR Deville 212 is too loud, but I have decided to hold on to it. The Fender DR, at 22 Watts fits the bill. What year should I look at (new, older, silver face etc) Thanks for the help. Derek

Response:

A DR is plenty loud at 22 watts. If you plan on cranking it in your apartment, your neighbors will still be awakened by the volume. If your goal is to obtain an amp that delivers power tube saturation at modest volume levels, then the DR is probably not what you would want…

– Hide quoted text — Show quoted text – I’d say silver face on back to their creation.Thats just going by the articles I’ve read about them though I’m looking to add a fender deluxe reverb to my arsenal. I need something that can be cranked but not wake the neighbors in the next county. My HR Deville 212 is too loud, but I have decided to hold on to it. The Fender DR, at 22 Watts fits the bill. What year should I look at (new, older, silver face etc) Thanks for the help. Derek

Response:

I thought a DR would be a good choice if only that it is about one third the power of my HRD 212. So does anyone have any insight as to what would be a good choice? A champ is definitely not an alternative. I already have one for practice. I Any rebuttles, coments, or whatever. I am only pestering y’all because I dont have a decent music shop in my area to try out some amps.

Response:

Hello Derek, Since you have an amp that meets your apparent needs for gigging and jamming with friends, and you have a Champ for home practice, I’d recommend a good quality overdrive pedal so that you can get your edge, overdrive and sustain at lower amp volume. The volume controls work both ways, and if your Fender Deville is loud enough for your higher volume needs, why not turn the amp volume control down, set the amp up for clean, and use an overdrive pedal to give you sustain and edge? AnalogMike is a good source for TS – 9 pedals. I favor the Barber Electronics pedals like the Tone Pump and the Burn Unit myself. To my mind you don’t gain a whole lot by a Deluxe, unless you decide that you like the tone and sound of the amp. You can turn your Deville down and you have options to increase sustain and overdrive through a pedal. If you just plain want to buy another amp, go for it and experiment. Of course, what do I know – I’m a Marshall guy (grin…). Maybe something to consider is whether or not your Deville will allow an extension cab; if so, you may want to consider looking at something like a Dr. Z amp and using your Deville speakers until you can find a 2 x 12 cab that might work both for the Dr. Z amp or as an extension cab for the Deville. I’ve heard very little negative about Dr. Z amps and a lot of positive stuff; never played one myself but people who I respect have posted here that they really enjoy their Dr. Z amps. Might give you another sound to your tone palette and something different from your Fender. Good luck to you in your search; enjoy your music! Walk in Beauty, Peace. Scott – Hide quoted text — Show quoted text – A DR is plenty loud at 22 watts. If you plan on cranking it in your apartment, your neighbors will still be awakened by the volume. If your goal is to obtain an amp that delivers power tube saturation at modest volume levels, then the DR is probably not what you would want… I thought a DR would be a good choice if only that it is about one third the power of my HRD 212. So does anyone have any insight as to what would be a good choice? A champ is definitely not an alternative. I already have one for practice. I Any rebuttles, coments, or whatever. I am only pestering y’all because I dont have a decent music shop in my area to try out some amps.

Response:

I thought a DR would be a good choice if only that it is about one third the power of my HRD 212.

1/3 the power is barely like 10 db quieter. ANYTHING you push to compression/distortionis going to disturb the neighbors unless you pad out a closet to keep the sound in. the Fender Blues Junior is a great small amp, but STILL is going to cut some sound. Even a pignose pushed is louder than a TV set turned up loud enough to bother neighbors. A screaming guitar amp makes a lot of noise. It’s why the ROCKMAN was invented decades ago…. — Perspective is vital to wisdom. It is indeed a good thing to know that for every ELECTRIC LADYLAND there were months/years/decades of tracking The Archies. – Hide quoted text — Show quoted text – Help Keep The Net Emoticon Free! <<

Response:

I am only pestering y’all because I dont have a decent music shop in my area to try out some amps.

Then you need to get to travel to one or more. My opinion is that these lesser-power needs are better served (and play better as well) through sand-state amps.

Response:

My opinion is that these lesser-power needs are better served (and play better as well) through sand-state amps.

I knew I’d get at least one response that I wouldnt understand

Response:

good choice if only that it is about one third the power of my HRD 212. So does anyone have any insight as to what would be a good choice? A champ is definitely not an alternative. I already have one for practice. I

As a low-cost alternative, consider hooking your Champ up to a small cabinet. The tone will improve 1,000% over the stock 8" speaker. I plug my Champ into a 4 Ohm, 2 x 12" cabinet and find it loud enough to lead a small group when cranked, but not too loud as to wake up the old lady next door at 5. The tone is wonderful, too. IMO, a Champ and a 2×12" is a hard combination to beat for practice.

Response:

I have a homebrew champ with 4 and 8 ohm taps on the OPT. I switch to 8 ohms when I want to use the 4 x 10 Marshall cab. Very cool but very directional. With the open back 10" Celestion in the amp it’s much "fuller" and quieter. I also put the Marshall cab under my ‘71 SFDR occasionally. The Fender has a weber P12N and sounds great. Then add the 4 x 10 and woo hoo! Have you tried running the Champ thru the speakers in the HR? Is the HR 4 ohms total? You may want reverb here. I use an electronic reverb with the "Champ" (and the Harmony H415 I re-built.) . The H415 has 2 el84 and 2 x 12" Jensen C12R speakers. Raw and meaty. see details: http://www.geocities.com/jjsant/harmony.html To actually answer your question. I would by an early SF. 1967/8 with the metal trim around the edge. I have seen a few beautiful ones on ebay. If you don’t want to spend the extra $ for the more collectable ones, get a 1977 or sooner with NO push pull. Those are evil and will cause negative vintage ju ju. JJman

Response:

Jny Vee- I was going to say more or less what you already said as I think you are correct in everything you wrote. As a DRRI owner, I can’t use it in my own house, with no neighbors to worry about, past 4 or 5 on the volume without blowing my own eardrums out. So I just thought I’d help with an understanding of one trivial fact, which, unfortunately, doesn’t help the original poster but may throw a little light on the subject. You wrote, "1/3 the power is barely like 10 db quieter". Actually, I think it’s a lot LESS than 10db. Each 3db is a halving of power. So, a reduction from 60 watts to 30 watts is only 3db. To get to 6db quieter, you’d have to go down to 15w. At 22 w, the DR is probably only around 4-5db quieter than his 60w amp. I think, if I recall correctly, that 1db is a change that is just barely perceptible to the human ear. And that’s probably why he will have trouble finding any amp to fill that particular need.

– Hide quoted text — Show quoted text – A DR is plenty loud at 22 watts. If you plan on cranking it in your apartment, your neighbors will still be awakened by the volume. If your goal is to obtain an amp that delivers power tube saturation at modest volume levels, then the DR is probably not what you would want… I thought a DR would be a good choice if only that it is about one third the power of my HRD 212. 1/3 the power is barely like 10 db quieter. ANYTHING you push to compression/distortionis going to disturb the neighbors unless you pad out a closet to keep the sound in. the Fender Blues Junior is a great small amp, but STILL is going to cut some sound. Even a pignose pushed is louder than a TV set turned up loud enough to bother neighbors. A screaming guitar amp makes a lot of noise. It’s why the ROCKMAN was invented decades ago…. — Perspective is vital to wisdom. It is indeed a good thing to know that for every ELECTRIC LADYLAND there were months/years/decades of tracking The Archies. Help Keep The Net Emoticon Free! <<

Response:

I picked up a Piggie GV40 for next to nothing, retubed it with JJs and added a vintage Jenson 10 and at 40 watts, it is more than enough for home, but still breaks up nice when pushed.

Response:

I had a Dr. Z Carmen Ghia and liked it very much. It was a head version that I ran through a home-made 2X12 Vitage 30 cabinet. It sounded great – a rather loud 18w. I just sold it to get a larger Dr. Z Maz 38 Studio head. Very highly recommended. Not cheap, but not built cheap either. A used Carmen Ghia head can be had for around $600 on ebay (or so). I had a fancy hardwood front and Telefunkens in mine, so I just got a bit more than that out of it. The Maz series amps are more expensive yet. – Hide quoted text — Show quoted text – Hello Derek, Since you have an amp that meets your apparent needs for gigging and jamming with friends, and you have a Champ for home practice, I’d recommend a good quality overdrive pedal so that you can get your edge, overdrive and sustain at lower amp volume. The volume controls work both ways, and if your Fender Deville is loud enough for your higher volume needs, why not turn the amp volume control down, set the amp up for clean, and use an overdrive pedal to give you sustain and edge? AnalogMike is a good source for TS – 9 pedals. I favor the Barber Electronics pedals like the Tone Pump and the Burn Unit myself. To my mind you don’t gain a whole lot by a Deluxe, unless you decide that you like the tone and sound of the amp. You can turn your Deville down and you have options to increase sustain and overdrive through a pedal. If you just plain want to buy another amp, go for it and experiment. Of course, what do I know – I’m a Marshall guy (grin…). Maybe something to consider is whether or not your Deville will allow an extension cab; if so, you may want to consider looking at something like a Dr. Z amp and using your Deville speakers until you can find a 2 x 12 cab that might work both for the Dr. Z amp or as an extension cab for the Deville. I’ve heard very little negative about Dr. Z amps and a lot of positive stuff; never played one myself but people who I respect have posted here that they really enjoy their Dr. Z amps. Might give you another sound to your tone palette and something different from your Fender. Good luck to you in your search; enjoy your music! Walk in Beauty, Peace. Scott A DR is plenty loud at 22 watts. If you plan on cranking it in your apartment, your neighbors will still be awakened by the volume. If your goal is to obtain an amp that delivers power tube saturation at modest volume levels, then the DR is probably not what you would want… I thought a DR would be a good choice if only that it is about one third the power of my HRD 212. So does anyone have any insight as to what would be a good choice? A champ is definitely not an alternative. I already have one for practice. I Any rebuttles, coments, or whatever. I am only pestering y’all because I dont have a decent music shop in my area to try out some amps.

Response:

Hello, Thanks for your reply. The Dr. Z amps look like one of the best bangs out there; glad you like his line of amps. Have a great Thanksgiving; enjoy your gift of being able to create and play music. Walk in Beauty, Peace. Scott

– Hide quoted text — Show quoted text – I had a Dr. Z Carmen Ghia and liked it very much. It was a head version that I ran through a home-made 2X12 Vitage 30 cabinet. It sounded great – a rather loud 18w. I just sold it to get a larger Dr. Z Maz 38 Studio head. Very highly recommended. Not cheap, but not built cheap either. A used Carmen Ghia head can be had for around $600 on ebay (or so). I had a fancy hardwood front and Telefunkens in mine, so I just got a bit more than that out of it. The Maz series amps are more expensive yet. Hello Derek, Since you have an amp that meets your apparent needs for gigging and jamming with friends, and you have a Champ for home practice, I’d recommend a good quality overdrive pedal so that you can get your edge, overdrive and sustain at lower amp volume. The volume controls work both ways, and if your Fender Deville is loud enough for your higher volume needs, why not turn the amp volume control down, set the amp up for clean, and use an overdrive pedal to give you sustain and edge? AnalogMike is a good source for TS – 9 pedals. I favor the Barber Electronics pedals like the Tone Pump and the Burn Unit myself. To my mind you don’t gain a whole lot by a Deluxe, unless you decide that you like the tone and sound of the amp. You can turn your Deville down and you have options to increase sustain and overdrive through a pedal. If you just plain want to buy another amp, go for it and experiment. Of course, what do I know – I’m a Marshall guy (grin…). Maybe something to consider is whether or not your Deville will allow an extension cab; if so, you may want to consider looking at something like a Dr. Z amp and using your Deville speakers until you can find a 2 x 12 cab that might work both for the Dr. Z amp or as an extension cab for the Deville. I’ve heard very little negative about Dr. Z amps and a lot of positive stuff; never played one myself but people who I respect have posted here that they really enjoy their Dr. Z amps. Might give you another sound to your tone palette and something different from your Fender. Good luck to you in your search; enjoy your music! Walk in Beauty, Peace. Scott A DR is plenty loud at 22 watts. If you plan on cranking it in your apartment, your neighbors will still be awakened by the volume. If your goal is to obtain an amp that delivers power tube saturation at modest volume levels, then the DR is probably not what you would want… I thought a DR would be a good choice if only that it is about one third the power of my HRD 212. So does anyone have any insight as to what would be a good choice? A champ is definitely not an alternative. I already have one for practice. I Any rebuttles, coments, or whatever. I am only pestering y’all because I dont have a decent music shop in my area to try out some amps.

Response:

Hey Scott! I can see you messages again! They did some work on the news-server of my provider last week, and it seems now I can get your messages again… Great! Please tell me about your Super Lead again! Cheers, John. – Hide quoted text — Show quoted text – Hello, Thanks for your reply. The Dr. Z amps look like one of the best bangs out there; glad you like his line of amps. Have a great Thanksgiving; enjoy your gift of being able to create and play music. Walk in Beauty, Peace. Scott

Response:

Hello John, (Heh heh….) Thanks for your reply. Yeah, like you need to hear more about the amp that defines non-wimpy rock and blues (grin…). Seems like you own several Marshalls yourself, if memory serves me correctly. I’ve played a lot of amps, and my `74 SL half stack still defines (to me…) the holy grail of tone and sound, and I "got it." If I never purchased another amp in this life-time (may all our life-times be long and healthy and fun) I’d not feel like I was missing anything. I read posts about guys striving to find the tone and sound that does it for `em, and sure – I spent a lot of time and energy doing the same thing. The SL was "the amp" that I was looking for, and then when I had an excellent amp tech set it up for me, that was what took a great amp and made it incredible to me. Growing up in the midwest of the USA (I’m 51) we didn’t know much about fine-tuning amps via an amp tech – we plugged in and if it sounded decent, we ran with it. It was Fender-land and I couldn’t get the amps to do what I wanted. Kudos to all the Fender guys on this NG; just not my line of amps. This excellent newsgroup helped educate me to the extent that I eventually understood what a good amp tech could do with a great amp, and the proof is my SL. Louder than blazes when I want it to be, cleans up well when I roll the guitar volume down, interacts very well with a quality overdrive pedal, and is such fun to play. When I got the amp back from the tech, I had that same experience that many players do when they have "the right amp" for their needs – I played for hours and had so much fun, it was hard to stop playing. Well, I guess I "did" say something about my SL (grin….) after all. How are your Marshalls doing, John? Got a fav that you look forward to playing? Best wishes across the big pond; our family had a great Thanksgiving today and I’m finally feeling like I won’t explode or anything. An incredible buffet at one of our fancier hotels locally, and we didn’t have to do any dishes after we were done. Just paid the bill and walked, or rather, rolled and listed and tilted to side to side. Wow, what a feast. Then to top it off, I got several hours of playing a Les Paul into an old Silvertone combo (model 1472, in almost mint shape), and got most of my guitar fix done today. Walk in Beauty, Peace. Scott – Hide quoted text — Show quoted text – Hey Scott! I can see you messages again! They did some work on the news-server of my provider last week, and it seems now I can get your messages again… Great! Please tell me about your Super Lead again! Cheers, John. Hello, Thanks for your reply. The Dr. Z amps look like one of the best bangs out there; glad you like his line of amps. Have a great Thanksgiving; enjoy your gift of being able to create and play music. Walk in Beauty, Peace. Scott

Response:

Well, I guess I "did" say something about my SL (grin….) after all. How are your Marshalls doing, John? Got a fav that you look forward to playing? Best wishes across the big pond;

Thanks Scott.. My Marshalls are doing great! I’ve got 4 Marshalls (the Park45 included) and I’ve got a hard time choosing My favorites now are my ‘66 Park45 (actually a JTM45, currently running 6L6 tubes) for blues and my ‘72 50W Marshall 1987 (EL34’s) for rock. I currently ‘rediscovered’ my Les Paul, it sounds great with the 50 Watter. I’m using an Alessandro Muzzle power-attenuator with those. The Muzzle sounds very transparent, it’s a great for controling the volume of a non-MV amp in various situations (home & clubs). I can recommend a good attenuator (if you get tired of schlepping your ingenius baffle with your patented soundpads ). My ‘66 Super Bass is now being restored, it’s going to be very different from my Super Lead. I’ve discussed with my amp-tech that I wanted to go a different route with this amp (no need for two nearly identical sounding amps). The Super Bass is going to be voiced a bit darker with a looser feel and earlier brake-up than my Super Lead (which is tight, punchy and rather clean sounding…. but what a sound! ). I’ve also made a treble-booster (with a nifty rotatable-switch to select different input-caps) and a clean-boost (fullrange boost like your Micro-Amp). So I’m fooling around with them aswell… To make it short: I’m not bored and having a great time mixing and matching guitars/amplifiers and effects… Hmm… I’ve got to work on my technique a bit more Cheers, John.

Response:

Hello John, Wow, the various internet providers and assorted folks upstream from us had to walk this post of yours across the pond; it "just now" showed up through my newsreader, although it’s dated 11/29/02. Very strange. What a wonderful assortment of Marshalls you’ve got, John! That was a cool picture you sent me of the band you play in; you ought to post that for the AGA guys to see. I’m kind of thinking the same thing regarding my `69 Park 75. I don’t want a copy of my already great Super Lead. Perhaps just to take the amp to it’s full potential and be able to "hear" it’s voice and tone will be enough. I know that it’s not operating at it’s peak, nor has a good tech gone through it yet. One of my many projects that await the finances to do `em. Re-fretting my Tele is another project that I’ve got to do. Putting new speakers in an old hand-made 4 x 12 cab I used on the road in the early 70’s is another – several years ago I strengthened the internal construction of the cab and it’s now ready for some speakers, so I’ll eventually have two 4 x 12 cabs for my Super Lead. And getting two more Bill Lawrence pickups for my Strat; the bridge pickup he did for me is really fine and it really sings at stage volume. Oh yeah; when I win the lotto, I’m buying a local club just so that I’ve got a place to play loud and invite a few friends in for beverages. You get to do quite a bit when you’re the house band and you own the place (grin….). Just got to have that winning ticket first. Don Evans, who posts on AGA, just told me in another thread about a new compressor pedal that Dave Barber ("Tone Pump," "Burn Unit", and others) is working on. Don and I are favorably impressed with Barber’s work, and with his ear. www.barberelectronics.com . Glad you’re doing some work with your Les Paul. The LP/Marshall combination is a hard one to beat. Hey, I wanted to ask you if you ever use several of your Marshalls in a multi-amp rig, and if so – how do you like the sound and tone? Thanks for your reply, John. I hope you and your band are having fun and creating interesting and entertaining music. Have a great week. Walk in Beauty, Peace. Scott – Hide quoted text — Show quoted text – Well, I guess I "did" say something about my SL (grin….) after all. How are your Marshalls doing, John? Got a fav that you look forward to playing? Best wishes across the big pond; Thanks Scott.. My Marshalls are doing great! I’ve got 4 Marshalls (the Park45 included) and I’ve got a hard time choosing My favorites now are my ‘66 Park45 (actually a JTM45, currently running 6L6 tubes) for blues and my ‘72 50W Marshall 1987 (EL34’s) for rock. I currently ‘rediscovered’ my Les Paul, it sounds great with the 50 Watter. I’m using an Alessandro Muzzle power-attenuator with those. The Muzzle sounds very transparent, it’s a great for controling the volume of a non-MV amp in various situations (home & clubs). I can recommend a good attenuator (if you get tired of schlepping your ingenius baffle with your patented soundpads ). My ‘66 Super Bass is now being restored, it’s going to be very different from my Super Lead. I’ve discussed with my amp-tech that I wanted to go a different route with this amp (no need for two nearly identical sounding amps). The Super Bass is going to be voiced a bit darker with a looser feel and earlier brake-up than my Super Lead (which is tight, punchy and rather clean sounding…. but what a sound! ). I’ve also made a treble-booster (with a nifty rotatable-switch to select different input-caps) and a clean-boost (fullrange boost like your Micro-Amp). So I’m fooling around with them aswell… To make it short: I’m not bored and having a great time mixing and matching guitars/amplifiers and effects… Hmm… I’ve got to work on my technique a bit more Cheers, John.

Response:

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Category: Discontinue Use Of Zoloft In Lewy Body Caus
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Prescription Medication Knowledge Base » Eessential Tremor Effexor » Tardive Dyskensia

Tardive Dyskensia

Question:

What Makes Tics Tick? Clues Found in Tourette Twins’ Caudates August 1996 For the first time, scientists have a neurobiological explanation for the variation in severity of tics in Tourette Syndrome. Researchers at the National Institute of Mental Health have traced such symptom differences to "supersensitivity" of certain neurotransmitter receptors in the brain structure responsible for carrying out automatic behaviors. They suggest that this dysfunction may underlie the compulsion to act out the sudden movements and vocalizations that characterize Tourette Syndrome, which affects about 100,000 Americans with its full-blown form and up to 0.5% of the population with milder symptoms. The researchers report on their findings in the August 30th issue of Science. In a brain imaging study of identical twins differently affected by the disorder, Daniel Weinberger, M.D., Steven Wolf, M.D., and colleagues in the NIMH Clinical Brain Disorders Branch found that binding to D2 dopamine receptors in the caudate nucleus was higher in the sibling with the more severe symptoms. "Strikingly, the degree to which the twins differed in this caudate D-2 binding predicted almost absolutely their differences in tic severity," said Weinberger. "This also likely explains the ebb and flow of tics experienced over the course of Tourette Syndrome and its overlap with obsessive compulsive disorder. "While we know that genetics plays an important role in transmission of Tourette Syndrome, the fact that identical twins show differences in symptom severity suggests that environmental influences modify the clinical expression of the disorder," he explained. "We studied identical twins discordant for such symptom severity to control for normal genetic variation in brain function." Although previous studies comparing unrelated Tourette patients with unaffected persons had failed to show differences in dopamine system function, the NIMH investigators were spurred by the fact that Tourette symptoms respond to drugs like haloperidol that block D2 dopamine receptors. They used a radioactive tracer drug, IBZM (iodobenzamide), that similarly blocks D2 receptors, and a SPECT* (single-photon emission computed tomography) scanner to image dopamine binding in five identical twin pairs with the disorder. In each case, the differences were observed in the head of the caudate nucleus, but not in the adjacent putamen, suggesting that D2 caudate binding accounted for almost all of the symptomatic variance within each twin pair. Previously, preoccupation with the motoric aspects of Tourette Syndrome had led researchers to search for clues in the putamen, according to Weinberger. Subtle changes in receptor availability in one small area appear to explain rather large differences in clinical presentation, say the researchers. Functional brain imaging studies of OCD (obsessive compulsive disorder), which often occurs along with Tourette Syndrome, also implicate a brain circuit that includes the head of the caudate nucleus, along with areas in the frontal and cingulate cortex. Thus, the new NIMH finding adds to evidence that the disorders are "overlapping neurobehavioral conditions," suggest the researchers. They speculate that the caudate nucleus may be related to the compulsive component of tics, whereas the dopamine dysfunction there may be the "common link between the ideational and motor components of Tourette Syndrome." Other NIMH researchers participating in the study included: Drs. Douglas Jones, Michael Knable, Thomas Hyde, Richard Coppola, Kan Sam Lee, and Julia Gorey. Twin subjects were recruited by the Tourette Syndrome Association, Inc., which also provided partial funding for the study. Additional information and b-roll are available from the association (718-224-2999). Information provided by the NIMH. *The SPECT scanner employs radiation detectors to get a fix on the location in the brain of a tracer drug. Unlike other similar techniques, such as PET (positron emission tomography), SPECT uses a tracer with a long half-life, making possible studies such as this one, which involved a prolonged series of scans over a 4-hour period. http://www.mhsource.com/hy/tic.html

Response:

Hi Elaine, http://www.dystonia-foundation.org/defined/forms.asp This is a link to they Dystonia Research Foundation website. You can check your symptoms with Ormandibular or Meige These are focal forms of Dystonia, which is a movement disorder. These are sometimes caused from side effects from certain medications. I have Blepharospasm which affects the eyes and Meige which affects the face. Facial tics and Meige are very similar. The best type of doctor for diagnosing would be a Movement Disorder Specialist. I was watching Oprah the other day, it was about Tourettes. It was an excellent show. I was very interested in the similaraties of finding things that we can do to get a rest from the movements (tics) they showed a girl who can act and sing on stage tic free. The other things were how we feel inside living and coping with this. The show came about from the book "Icy Sparks" which talks about emotions. Sounds like a great book. Please come back and let us know how you are doing. Best Wishes, Mindy – Hide quoted text — Show quoted text -Hi, I was doing a search online, and obtained a reference to this newsgroup for possible help. I have Tourette Syndrome and have been on different medications over the years. Recently, I was taking Prolxin. When I stopped, a new tic appeared (which is common with TS — for tics to come and go and change). This tic was in my face though and hasn’t followed the usual course of tics I have had in the past. I am concerned that this is not part of TS but rather Tardive Dyskensia caused from taking Prolixin. At this point, I am not sure what to do, or what can be done. I contacted the doctor who prescribed the Prolixin who is located in Houston. (I live in Albuquerque). He said I should make an appointment to come in for an exam. While this may be the best thing to do, I am concerned, since he was the one who prescribed the Prolixin to begin with. My symptoms include movements in my face, particularly the right side of my face in my jaw and check area. It has become quite painful for my jaw. It is a facial contortion that somewhat looks like chewing, and also smacking with my lips. I have read some information that the earlier it is detected the better the chance it will disappear. I don’t know if there is a treatment for this or not. I also have started taking Vitamin E, as I ran across this information as well as something that could potential help. I would appreciate any advice that I can get from anyone who has information regarding this. thanks, elaine

Response:

Hi, I was doing a search online, and obtained a reference to this newsgroup for possible help. I would appreciate any advice that I can get from anyone who has information regarding this. thanks, elaine

Hi Elaine, I had a no no tic for a few years and can really sympathize with you. Tics are so exhausting and embarrassing. Onset started after taking medication for an ulcer. The prescrition’s name is unknown. I only made the connection between onset and the medication years later. I was never treated for the tic. It went away on its own. I do have essential tremor and Dystonia. Please check out the following sites for more http://www.wfubmc.edu/surg-sci/ns/tremor.html http://www.parkinsons-information-exchange-network-online.com/archive… Regards, Gene

Response:

Hi, I was doing a search online, and obtained a reference to this newsgroup for possible help. I have Tourette Syndrome and have been on different medications over the years. Recently, I was taking Prolxin. When I stopped, a new tic appeared (which is common with TS — for tics to come and go and change). This tic was in my face though and hasn’t followed the usual course of tics I have had in the past. I am concerned that this is not part of TS but rather Tardive Dyskensia caused from taking Prolixin. At this point, I am not sure what to do, or what can be done. I contacted the doctor who prescribed the Prolixin who is located in Houston. (I live in Albuquerque). He said I should make an appointment to come in for an exam. While this may be the best thing to do, I am concerned, since he was the one who prescribed the Prolixin to begin with. My symptoms include movements in my face, particularly the right side of my face in my jaw and check area. It has become quite painful for my jaw. It is a facial contortion that somewhat looks like chewing, and also smacking with my lips. I have read some information that the earlier it is detected the better the chance it will disappear. I don’t know if there is a treatment for this or not. I also have started taking Vitamin E, as I ran across this information as well as something that could potential help. I would appreciate any advice that I can get from anyone who has information regarding this. thanks, elaine

Response:

What a great group! Thanks for the quick response and the links you have all recommended. This is the kind of doc I went to for my Tourettes. It is Dr. Jankovic at Baylor in Houston. It is a Movement Disorders clinic. Unfortunately, he is also the one who prescribed the Prolixin. I am currently trying to get an appointment with him again to try to figure out what is going on. He also mentioned botox treatment. Has this been successful for any of

you? Several months ago, I heard that someone had gone to Dr. Jandovic in Houston, also for Tourettes and received botox injections. Apparently, it is being done but I never heard anything else from this young man as to success. Botox is also being used for tics with success. Dr. Jankovic has a good reputation. I’ve heard from one lady here locally that saw him but she did not care for his bedside manner. She hasn’t been happy with any of her doctors, though. She has Blepharospasm symptoms but apparently keeps getting different diagnoses depending on where she goes. Shirley

Response:

Dr. Jankovic, apparently, is one of the top in his field. He has an excellent reputation. He also mentioned botox treatment. Has this been successful for any of you?

Botox is used on focal dystonias. Many patients have had good results with it. – Hide quoted text — Show quoted text -Several months ago, I heard that someone had gone to Dr. Jandovic in Shirley

Response:

Hi Mindy, It has been very helpful! I am grateful for the information. Positive thinking – BINGO Stress Management and Humor are the best medicines. I can’t forget God and prayer, is #1

Yes, I can see where all of these would be important. I have noticed stress plays a big part in the disorder. It does in Tourettes as well, but seems to be more so with this. the eye twitch you refer to I might describe as a soft fluttering feeling.

right, that is what I a good example… Our eye spasms are involuntary but they are hard blinks, sometimes forecful. Other times they close and will not open on command. These type of spasms are very noticable. The eye and facial spasms are extremely hard to suppress.

Tics from tourettes are involuntary as well, but there is this sense at some level that you "should" be able to stop the movement. I feel this as well with whatever is going on with my face. Even though realistically it doesn’t feel like I can stop it, it also doesn’t feel as involuntary as the eye twitch described above. It also seems much harder to suppress than tics that I normally have with TS. It also feels like it is getting worse. I don’t know if that is from stress or maybe from being off the offending medication for a longer period of time. Its very confusing! And painful… Just like TS, when I do try to suppress it, it is only short lived. It seems to be more prevalent in frequency as well compared to the tics I have with TS. That is exactly what happens. It would help if I laid down closed my eyes, opened my mouthly slightly, relaxing my jaw and my face. I would take slow deep breaths and focused on relaxing each part of my body from my head to my toes (very slowly, as I said the words to my self, relax your head, etc.) and don’t move on until each part is relaxed.

I will try this as well. It would be nice to get some relief. Dr.Jankovic is well known. I don’t know anything about him personally. I go to Dr. Bressman in Manhattan, she is an excellent doctor. She has tried me on many meds that didn’t agree with me at all. These types of disorders require lot’s of patience from the doctor as well as the patient to see which meds. or combination of meds. that will help. Life would be much easier if we all responded the same way to these meds. but, we don’t, unfortunately.

This is true for TS as well…except there really are no meds that really work with TS. Some will reduce tics, but none will make them go away. Unless for example, you take a neuroleptic in a high dose. In that case your tics would probably subside, but you wouldn’t be able to think! I’m pretty sure Dr.J. is one of the very dedicated doctors of this field. It’s important you have confidence in your doctor. Does he listen carefully and take his time with you? These things are also important.

I have only seen him once, last December. And he seemed pretty good. I e-mailed him about my frustrations of calling his office and not being able to get an appointment till December, and he wrote and said he would have his secretary arrange to overbook me on a day soon. So I was pleased to hear this. For a long time Dr.Bressman had me as "Meige vs. tics" She said it is so similar.

I can see that! I think that has been a big part of my confusion. They are so similar it is hard to tell them apart. She would ask if I felt the need to blink, before I blinked. It was hard for me to answer because it was always changing.

It is common with TS to have "premonitory" feelings before a tic. That is probably why she was asking you this. For example, I have a tic that is in my torso. Inevitably, when I get in the car to go somewhere, I "have to" tic. I twist my upper torso from left to right repeatedly, until it "feels right". And I can always tell before I tic that it is going to happen. If anything, the tic or problem with my face now feels more like "a habit". That somehow it has become a habit for my jaw and mouth to contort about every 30 seconds or so. When I sleep, I don’t have it. I wake up in the morning and think, if I try really hard today, maybe it won’t come back. And it always does. Seems to get worse as the day progresses as well. I am hoping it is not damaging my jaw. It feels like it could be. It hurts into the jaw bone. I will be seeing my dentist next week, so I will ask if any damage has occurred. She said the treatment is the same. I was getting botox around my eyes and in my jaw. It did help me.. How long it helps varies with each person. About 2 yrs ago it stopped helping. Which worked out fine, cause presently I am on medication that is helping.

What medication is that? Are you experiencing any side-effects from it? When you do something creative that you are totally engrossed in, you get a reprieve from your tics. Stress makes them worse. During sleep, they are usually much better Is this true with dystonia as well? Another BINGO Many with dystonia we found from our discussions hum or sing or make some type of sound.

I haven’t found that doing something creative helps alleviate the facial movements at all. Actually, that was probably my first clue that it might not be a "normal tic" that I experience with TS. I haven’t tried humming or singing though…definitely worth a try! Also, many have problems breathing they tend to subside when the spasms are helped with medicine. Does this happen with TS?

No, breathing problems are not common with TS. I can see where I tend to breathe more shallow now because of this facial tic. It’s kind of like your whole body is taking a toll because of the tic. Kind of like your whole body tenses up, which then makes your breathing worse. But on a more physical level, like the feeling of asthma, I have not experienced that. Thanks for all the help! I really appreciate it. I am trying to learn as much as I can about this before I see Dr. Jankovic in the next couple of weeks. Have you had Meige all of your life of is it fairly recent? Do you know what caused it? thanks again, elaine

Response:

It has been very helpful! I am grateful for the information.

Me too )) It also feels like it is getting worse. I don’t know if that is from stress or maybe from being off the offending medication for a longer period of time. Its very confusing! And painful…

It might be a good idea if you write down all these feelings and symptoms because they are easy to forget. Take them with you when you go to the doctor. Leave a space between your questions, fill in with his replies. My sypmtoms started 8yrs. ago, it was my 40th birthday present (Ha Ha) (( I don’t know what caused it. My first few visits I took a small tape recorder with me, along with my husband and sister-in-law. None of us could have remembered everything, and we all walk out hearing something a little different – LOL For the pain, you can try moist warm heat or ice, you will get to know which makes you feel better. Don’t chew gum, that will give your jaw more of a work-out. You can suck on hard candy. That sucking action works the reverse of chewing. The dentist made me a mouth piece, nothing fancy, inexpensive. It’s clear rubber, molded from my teeth. I asked him to make the back a little thicker. I wore it mostly during the night. There were times when I needed it for driving (sounds strange) It really is very painful, and no one can understand how exhausting it can be, unless you’ve experienced it. Really all the dystonia movements are painful and exhausting. TS tics are not painful or exhausting? This is true for TS as well…except there really are no meds that really work with TS. Some will reduce tics, but none will make them go away.

BINGO – they don’t know the cause, and they don’t have a cure. Unless for example, you take a neuroleptic in a high dose.

My doctor told me Never Ever take any neuroleptics or dopamine blockers. There are lists of meds. that can cause dystonia. But strangely enough many on that list are prescribed to help dystonia. Let’s hope and pray if yours came from that med. it will subside and go away. I was given meds that gave me crazy side effects like making my arms fling about, and my head shake, etc. They did go away when the med. was out of my system. I e-mailed him about my frustrations of calling his office and not being able to get an appointment till

It does get frustrating, between the doses, and symptoms, there was always questions. I ended up goint to a psychiatrist in my neighborhood who is board certified in psychiatry and neurology to monitor my meds. He was in contact with my Movement Specialist, and I don’t take anything unless she ok’s it. When I sleep, I don’t have it. I wake up in the morning and think, if I try really hard today, maybe it won’t come back. And it always does. Seems to get worse as the day progresses as well.

Dystonia spasms go away while sleeping. It helps to get a good nights sleep, and a nap in the afternoon. I remember waking up with those exact feelings. What medication is that? Are you experiencing any side-effects from it?

I’m taking Parsitan, (My psych.does not monitor this med) It’s not sold in the States. I get it from Canada. I notice some short term memory loss. I haven’t found that doing something creative helps alleviate the facial movements at all.

I was able to crotchet, gardening, be on the computer, these would alleviate the movements, most of the time. I actually thought I could re-train my brain by doing something that kept my eyes open, I would stay at it for hours, days, months -LOL I still keep my hopes up that my brain will work around the mis-fired neurotransmitters. Positive thinking LOL I can see where I tend to breathe more shallow now because of this facial tic. It’s kind of like your whole body is taking a toll because of the tic. Kind of like your whole body tenses up, which then makes your breathing worse.

I think you hit the nail on the head. If you pracitce deep breathing excersises everyday, it will automatically kick in when you need it. It takes a long time, but the everyday benefits are definately worth it. Not only for us, for everyone. It’s great for mind and body. Thanks for all the help! I really appreciate it. I am trying to learn as much as I can about this before I see Dr. Jankovic in the next couple of weeks.

I’m really enjoying our chit-chat Marie and Shirley have the same type of dystonia as I do. Hey Marie & Shirley, we could use your 2 cents thanks again, elaine

thank you, Elaine, Mindy – Hide quoted text — Show quoted text –

Response:

What a great group! Thanks for the quick response and the links you have all recommended. I had a no no tic for a few years and can really sympathize with you. Tics are so exhausting and embarrassing.

yes. they sure can be! it is a bizarre disorder… I was never treated for the tic. It went away on its own. I do have essential tremor and Dystonia.

I am hoping that I caught this soon enough and it will go away…positive thinking! It is interesting that you have essential tremor. When I went to see a new specialist last December regarding my Tourettes, he did a standard neurological evaluation and also told me I had essential tremor. I had known for years that my hands would shake for no apparent reason. Primarily when I tried to do fine detail work. Interestingly enough, I am a graphic designer. Most of my work now is done on computer. But in the past, and still when I paint or illustrate, if I am really focused, my hands don’t seem to shake. Yet, if I am doing something "non-creative" like trying to screw in a screw or solder something, they shake so much it is hard to be effective. My hands have been this way so long that I just thought it was me…so I was surprised when my doc had a term to describe it. You can check your symptoms with Ormandibular or Meige…

<snip thanks for the links… one of my questions is that in the description of these disorders, it describes it many times as being a "spasm" What is happening with me, doesn’t feel like a spasm. We sometimes have discussions like this on Tourettes lists that I am on, so I am sure you have discussed how these movements "feel"… To me a spasm feels more involuntary. For example, an eye twitch. This is a common experience that most people experience at different times in their life. The muscle twitches, fairly rapidly and the person has absolutely no control over it. Is that what dystonia is like? That is not what is happening for me. This movement is actually very similar to the tics I experience with Tourettes — if I really try, I can somewhat suppress this movement. The thing that feels different with the facial movements I am describing to you compared to the tics I normally feel with TS is that it is more difficult to suppress the movement. Just like TS, when I do try to suppress it, it is only short lived. It seems to be more prevalent in frequency as well compared to the tics I have with TS. The best type of doctor for diagnosing would be a Movement Disorder Specialist.

This is the kind of doc I went to for my Tourettes. It is Dr. Jankovic at Baylor in Houston. It is a Movement Disorders clinic. Unfortunately, he is also the one who prescribed the Prolixin. I am currently trying to get an appointment with him again to try to figure out what is going on. He also mentioned botox treatment. Has this been successful for any of you? I was watching Oprah the other day, it was about Tourettes. It was an excellent show.

Yes, it was very well done! There were a lot of shows in the past that only showed the sensationalized aspects of Tourettes, so it was nice to see one that was accurate for a change! I was very interested in the similaraties of finding things that we can do to get a rest from the movements (tics) they showed a girl who can act and sing on stage tic free.

this seems to be fairly common with TS. When you do something creative that you are totally engrossed in, you get a reprieve from your tics. Stress makes them worse. During sleep, they are usually much better. Is this true with dystonia as well? Thanks again Gene and Mindy for your help! sincerely, elaine

Response:

I am French, though I don’t understand all the details of your conversation, I am very interested in reading your messages. I’ve been suffering from what is called "hemispasme" in French for about 8 years. Obviously it is not genetic but the symptoms are very similar to what I can read in some of your messages. It started slighly with my right eye as I was expecting my fourth child. No doctors could really help me, giving me neuroleptic which had all the possible effects on my body except on my eye. 2 years ago, I was about leaving my job I love so much, I couldn’t bear the spasms which occured every 30 seconds all day long. Though my life was harmonious, however I felt exhausted. My doctor sent me to a French specialist who started Botox. I have injections every three months, the medicine comes from the US and is not entirely recognized in France as it is considered as a "treatment for comfort !!". Besides, it is very expensive. I’ve had a new life since that time, though the right side of my face has changed a bit -people often ask me why I am so tired !. I perhaps look tired, but I feel very enthusiastic inside. I am 40 now and I wonder how long Botox will continue to help me. Have a nice day; Jo

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Prescription Medication Knowledge Base » Weight Gain A Side Effect Of Zoloft » feverfew

feverfew

Question:

Hello. I just found this newsgroup, so please forgive me if this question has been asked before: Does anyone know of any empirical studies on feverfew? I have used it for about five years (about two were used for determining the correct supplier, concentration, dosage, etc) and it has done wonders for me in decreasing the frequency and severity of my migraines. The problem is that when I do get the really bad migraines they are uncontrollable. On the advice of a (somewhat) trusted physician, I have recently stopped the feverfew in order to get some diagnostic tests done and to try IM Immetrex(sp?). I am a bit nervous that the preventative benefits of the feverfew will be lost if I stay off it for too long. I would like to find some good hard studies to give to my physicians, all of which doubt the effectiveness and safety of feverfew. Thanks in advance to anyone who can help. Carl (remove NOSPAM from address)

Response:

Hi Carl, Why not continue the feverfew if it works, and use Imitrex or Maxalt or Zomig for the ‘horrible’ ones?. Also, there are several Neurologists who suggest a baby aspirin a day or a ‘light’ aspirin every 2nd day to cut down on intensity and severity of migraines. This works for me, and Maxalt works great for the bad migraines. I tried feverfew for 8 months and it did not help at all. Most people who try it [Mygrafew in my case] don’t get any relief. I wish you luck. Email me any questions. Joyce

Response:

Joyce, Thanks for the message. I appreciate the advice. About feverfew: I needed advice from an herbologist (who specialized in pain relief) and from some of my relatives (who have been using it for their migraines) before I found the correct dosage, supplier, type, etc. to do me any good. One I did; however, I felt the effects in a few weeks. Here is what works best for me (and one of my friends): Retailer: GNC Brand: GNC Herbal Plus, Full Spectrum, (Feverfew, of course) Type: 125mg capsules, standardized to 0.5% parthenolides Dose: One capsule per day The problem with taking both Imitrex and feverfew is that the actions of both are similar, so there is no relief when the bad migraines appear (there is a synergistic effect that can initiate another headache). I do need to go off all supplements in order to be re-evaluated for migraines, so I have done so (reluctantly) until the tests are over. My physician gave me the IM Imitrex in case I had a migraine during that time, and also to determine the effects of the Imitrex if I had to use it while off the feverfew. I am allergic to aspirin, so can’t try your advice with that. Sounds interesting, though. I wonder if it is effective because of the counteraction of platelette aggregation or because of its action as a pain releiver? Haven’t tried Maxalt. What is it? Prescription or over-the-counter? Thanks again, and my wishes for many migraine-free days. Carl — – Hide quoted text — Show quoted text – Hi Carl, Why not continue the feverfew if it works, and use Imitrex or Maxalt or Zomig for the ‘horrible’ ones?. Also, there are several Neurologists who suggest a baby aspirin a day or a ‘light’ aspirin every 2nd day to cut down on intensity and severity of migraines. This works for me, and Maxalt works great for the bad migraines. I tried feverfew for 8 months and it did not help at all. Most people who try it [Mygrafew in my case] don’t get any relief. I wish you luck. Email me any questions. Joyce

Response:

writes: I could see why someone whose migraines had gotten better might just leave the group.

;-( Now I know why everyone has been so helpful, trying to cure my clusters!!! Bob Never Blame the Rainbows for the Rain [J.H.& R.T.]

Response:

(snipped) I could see why someone whose migraines had gotten better might just leave the group. Priscilla

You’re right Priscilla. I’ve been weaning myself away slowly, now, since the Imitrex has begun to work such wonders for me. I’ll still "lurk" (and enjoy all the sinister connotations that go with that desgination ; ) and maybe even make a smart aleck comment now and again, although I’m trying to wean myself away from those too! I have six days a month more time to read now!!!! And speaking of reading, I must get back ‘The Sparrow’. Thanks so much for recommending it although I sincerely hope you don’t expect me to write essays on the study questions in the back of the book! ; ) The only real difficulty I’ve had so far was in trying to tell Denny about the main character, ‘Sandoz’, and mistakenly calling him "Fiorinal"!!!! Anne : ) "We know the truth not only by the reason but also by the heart." Blaise Pascal

Response:

greetings… i just know that since taking feverfew my migraines have finally taken a break and left me alone… 3 months without a debilitating (2 days in bed) to a few minor ones ( 1 shot of imitrex) and now 3 weeks without any… i know this so hang in all and keep doing research and find out what works for you… but you have to research and try oh so many remedies/drugs etc.. take care

Response:

: Hi Wind Dancer, : Most of us here have suffered with migraines many years, including myself. : Have you noticed that most of us also, including me, are saying that they have : gotten worse in the last few years??? Makes me wonder why????? This may be because those whose migraines have gotten worse are more vocal, or maybe if your migraines have gotten worse you notice more the people whose migraines have done the same.

Or perhaps we have access (electronically) to more people than we did years ago. I personally know about a dozen people who get migraines. Add the considerable number of people I’ve "met" through this group and you skew the statistics considerably. — Dana ‘96 FXD-Conv "Roxie" Web: http://www.chaeron.com/danamania/ NOTE: Remove Spamicide ™ before replying!!!

Response:

Hi Wind Dancer, Most of us here have suffered with migraines many years, including myself. Have you noticed that most of us also, including me, are saying that they have gotten worse in the last few years??? Makes me wonder why????? ~~Heather~~

Response:

good morning all… i have to share this – i have been taking feverfew for 3 months now and have not had a debilitating migraine for 8 weeks (the 2 day in bed type) and have not had a sever (1 shot of imitrex) for 2 weeks. I have also started chiropractic care for the last 4 weeks… this is a first for me – i have had migraines since i was 10 years old – but never as bad as the last 1 1/2 years……there is hope for us all… we just have to research and find out what works for us.. take care

I’ve started going to a Chiropractice and it has helped. I used to get the ‘aura’ feel that something was going to happen. My neck would then really stiffen up and be sore, and a migraine would start. I still get the migraine headache, which I try to avoid with Imigran, but the neck pain is a lot better. It turned out that when I slept, I slept mostly in same position, on my front with my neck bent to the left. This made sense, when he said that after a week of this, it got too much for my neck and it hurt. On the migraine front now, I used to get it on Saturday when I relaxed and lay in. Now that I do skydiving at the weekends, I tend to feel rough mid week. At least my weekends are not so affected and I can enjoy the jumps and the parties! I’ll try taking Feverfew and see if that helps too. Belle.

Response:

I would try feverfew, but I am afraid of taking it with my daily inderal. I am worried about combining the herbs with the drugs.

Response:

Feverfew Nasal Mist, uses only when it is needed/

Response:

Feverfew Nasal Mist, uses only when it is needed/

Tell us more about this, please! — "It is useless to resent anything in this world." -E. Roosevelt oh, and please remove the "z" when replying by e-mail

Response:

I thought Feverfew was a miracle herb. And it was for 11 months. But then the migraines returned. I hope you do better.

Response:

Greetings from a longtime migraine sufferer, but new to this group. I have suffered from migraines since I was a child. I have found that daily feverfew is great at minimizing the nausea and vomiting part of migraines. Yes I still get them, but to at least not have the vomiting I can function until my Imitrex kicks in. Fortunately Imitrex works beautifully for me, since I have had no success with abortives like Inderal and Elavil. I have found that if I catch my migraine early and on an empty stomach then oral Imitrex works, but if it has gone beyond that early point then my only hope is injectable Imitrex. I am intrigued by the 5-HTP mentioned in someones note, so am going to get some today. I’d love to find an alternative to Imitrex, as I’m still leary about the potential longterm side efects which are yet unknown. I will try to keep in this ng loop, but due to my hectic schedule I may be spotty in my correspondence…….thanks

Response:

Of course, the alternative may be worse than the original med…all part of migraine roulette. Like many of you, I’m a triptan test case, hoping we don’t discover a few years down the road that we’ve permanently damaged something important. But I have to weigh that against the fact that I’m convinced I wouldn’t be here at all without SOMETHING for the pain. I, too, am trying the 5THP…have to keep trying. Welcome to the group! –Julianne

Response:

welcome mike!!! we’ll be happy to have you whenever your schedule permits. some of us (like myself) have so little a life, that we spend every day here, but it’s perfectly understandable that a hectic scedule permits little more than spotty correspondence. again,welcome!!!! Mike Barton wrote … Greetings from a longtime migraine sufferer, but new to this group.

….snip …. . – Hide quoted text — Show quoted text – I will try to keep in this ng loop, but due to my hectic schedule I may be spotty in my correspondence…….thanks

Response:

– Hide quoted text — Show quoted text – Greetings from a longtime migraine sufferer, but new to this group. I have suffered from migraines since I was a child. I have found that daily feverfew is great at minimizing the nausea and vomiting part of migraines. Yes I still get them, but to at least not have the vomiting I can function until my Imitrex kicks in. Fortunately Imitrex works beautifully for me, since I have had no success with abortives like Inderal and Elavil. I have found that if I catch my migraine early and on an empty stomach then oral Imitrex works, but if it has gone beyond that early point then my only hope is injectable Imitrex. I am intrigued by the 5-HTP mentioned in someones note, so am going to get some today. I’d love to find an alternative to Imitrex, as I’m still leary about the potential longterm side efects which are yet unknown. I will try to keep in this ng loop, but due to my hectic schedule I may be spotty in my correspondence…….thanks Hello Mike,

I’ve tried feverfew without noticing any difference and wonder if the dosage I’m using is incorrect. If you’re having success, I’ll gladly try whatever dosage you’re taking. Also what brand do you use? Carol –the sheer joy of being

Response:

the note. I take Migracare by Enzymatic Therapy which has 600mcg of parthenolide. I have tried less and it didn’t work and I’ve tried more with no greater effect. I know some products are available with up to 1200mcg. Perhaps – Hide quoted text — Show quoted text – Greetings from a longtime migraine sufferer, but new to this group. I have suffered from migraines since I was a child. I have found that daily feverfew is great at minimizing the nausea and vomiting part of migraines. Yes I still get them, but to at least not have the vomiting I can function until my Imitrex kicks in. Fortunately Imitrex works beautifully for me, since I have had no success with abortives like Inderal and Elavil. I have found that if I catch my migraine early and on an empty stomach then oral Imitrex works, but if it has gone beyond that early point then my only hope is injectable Imitrex. I am intrigued by the 5-HTP mentioned in someones note, so am going to get some today. I’d love to find an alternative to Imitrex, as I’m still leary about the potential longterm side efects which are yet unknown. I will try to keep in this ng loop, but due to my hectic schedule I may be spotty in my correspondence…….thanks Hello Mike, I’ve tried feverfew without noticing any difference and wonder if the dosage I’m using is incorrect. If you’re having success, I’ll gladly try whatever dosage you’re taking. Also what brand do you use? Carol –the sheer joy of being

Response:

has anyone tried this natural herb.. i have been using it for 5 weeks and have not had a "severe" type (usually sends one to bed for 2 days) – they have been milder and i can function.. would like to hear feedback thanks

Response:

I’ve been taking Feverfew for a couple of months now, and have had 2 severe (go to bed) migraines during that time. Which, for me, is an improvement. I don’t think it’s a miracle or anything, but I do think it’s helping some. — Dana Taramina Web: http://www.chaeron.com/danamania/ NOTE: Remove Spamicide ™ before replying!!!

Response:

Yes!!! I started taking Feverfew (1 380 mg. capsule per day) about three months ago, and have reduced both the frequency and severity of my migraines considerably. In case I wasn’t sure , I somehow forgot to take them for a few weeks recently and the old #9-10 headaches were back with a vengance. I am a believer, for sure. Good luck. By the way, I have noticed no side effects at all and can even take it on an empty stomach! Molly

Response:

Feverfew is an herb, and it is effective for some, but usually only after taking it for quite a while – months sometimes. My grandmother grew it when I was little and made us eat the leaves or drink tea from its leaves everyday, to "ward off evil in the body" as she said. If it was going to work for you, it probably would have needed more than 3 weeks, and from what I understand, the new capsules and store brands have the same natural "weaknesses" of all other organic cures

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Category: Weight Gain A Side Effect Of Zoloft
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Prescription Medication Knowledge Base » Zoloft Xanax » Anxiety or OCD

Anxiety or OCD

Question:

Hi, There is no physical test (blood, etc.) that can determine if you have OCD. The only way is to describe your symptoms and feelings to the pdoc. You may want to schedule a normal exam with your regular doctor to rule out any other physical problems. That would be up to you. A Zoloft/Xanax combination would be a good first choice for someone with OCD or OCD like tendencies. Why do you think you may have OCD? The symptoms you describe below could be OCD, or they might be a lot of other things. Are your thoughts consistently about "bad" things that may happen, or are they "going over" everyday events and worries? Do you repeat the same thought over and over or do you think about a lot of different things? Do you have any physical compulsions like checking and rechecking things, or hoarding things? I’m kind of interested in this sort of stuff, because I have OC tendencies a lot of times, but I don’t believe I have OCD. I believe I may have a personality disorder that is kind of similar to OCD but is not the same. – Hide quoted text — Show quoted text – I have what i though was anxiety attacks. as i have read up on things it appears i have many similarities with OCD. i have been going to a phsychiatrist but he wasn’t really the one for me. he imediatly put me on Zoloft, with out any tests or checkups. I have reaccurring thoughts about everything. i just can’t seem to "get over things". i constantly concentrate on physical flaws i feel i have. i think the biggest problem is dealing with things. i can’t seem to think clearly or objectively. my thoughts are constantly crowded with the same thoughts over and over. the phsychiatrist also gave me xanax, which helps alot, but i have heard bad things about the drug like depression and dependance. can someone please give me some insight. anything would be good right now. — Posted via Talkway – http://www.talkway.com Exchange ideas on practically anything ™.

Response:

I have what i though was anxiety attacks. as i have read up on things it appears i have many similarities with OCD. i have been going to a phsychiatrist but he wasn’t really the one for me.

Find another pdoc if you aren`t happy with this one. Only a pdoc can diagnosis you. OCD is a anxiety disorder, and you can have panic disorder and OCD at the same time, that is why you need to see a new doctor and get diagnosed. he imediatly put me on Zoloft, with out any tests or checkups.

A pdoc is not going to test you or do a checkup on you. He will diagnosis you by what you tell him. It is always a good idea to go to a medical doctor for a complete physical and to make sure there is no physical reason for your symptoms. A Pdoc will not do this for you. Zoloft can be quite effective for anxiety and OCD. It does take 6 to 8 weeks to become effective though. I have reaccurring thoughts about everything. i just can’t seem to "get over things". i constantly concentrate on physical flaws i feel i have. i think the biggest problem is dealing with things. i can’t seem to think clearly or objectively. my thoughts are constantly crowded with the same thoughts over and over. the phsychiatrist also gave me xanax, which helps alot, but i have heard bad things about the drug like depression and dependance. can someone please give me some insight. anything would be good right now.

It is good to take the Xanax while weaning on the Zoloft. I haven`t seen many people here complain of depression while on Xanax, and if that were to happen there are other benzo`s you can take. You will become dependent on the Zoloft as well as the Xanax, and all that means is you will have to stop the meds slowly when the time comes. Many meds cause a physical dependency and this shouldn`t be confused with *addiction*. If you use the Xanax as prescribed by your doctor you will not get addicted to it. Take care!!!! Jackie

Response:

I have what i though was anxiety attacks. as i have read up on things it appears i have many similarities with OCD. i have been going to a phsychiatrist but he wasn’t really the one for me. he imediatly put me on Zoloft, with out any tests or checkups. I have reaccurring thoughts about everything. i just can’t seem to "get over things". i constantly concentrate on physical flaws i feel i have. i think the biggest problem is dealing with things. i can’t seem to think clearly or objectively. my thoughts are constantly crowded with the same thoughts over and over. the phsychiatrist also gave me xanax, which helps alot, but i have heard bad things about the drug like depression and dependance. can someone please give me some insight. anything would be good right now. — Posted via Talkway – http://www.talkway.com Exchange ideas on practically anything ™.

Response:

- Hide quoted text — Show quoted text -I have what i though was anxiety attacks. as i have read up on things it appears i have many similarities with OCD. i have been going to a phsychiatrist but he wasn’t really the one for me. he imediatly put me on Zoloft, with out any tests or checkups. I have reaccurring thoughts about everything. i just can’t seem to "get over things". i constantly concentrate on physical flaws i feel i have. i think the biggest problem is dealing with things. i can’t seem to think clearly or objectively. my thoughts are constantly crowded with the same thoughts over and over. the phsychiatrist also gave me xanax, which helps alot, but i have heard bad things about the drug like depression and dependance. can someone please give me some insight. anything would be good right now. — Posted via Talkway – http://www.talkway.com Exchange ideas on practically anything ™.

Hi, How long have you been on the zoloft? I’m pretty sure that SSRI’s are standard treatment for OCD as well as anxiety. I think luvox is used frequently for OCD. Sometimes it takes weeks for an AD to kick in. I don’t think I have OCD, but being on an SSRI has eliminated 99% of my worries, and ruminations. Haven’t heard of too many people here depressed from xanax. It didn’t affect me that way. If you are worried about dependence on xanax, there are ways to taper off of it. If your still having the recurring thoughts/anxiety while on zoloft after 8 weeks, it might not be the correct med for you. Maria

Response:

OCD is an anxiety disorder. Panic disorder, post-traumatic stress disorder, phobias, generalized anxiety disorder are all ANXIETY DISORDERS.

Response:

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Category: Zoloft Xanax
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Prescription Medication Knowledge Base » Prozac Effexor » Zoloft to Prozac or other ADs

Zoloft to Prozac or other ADs

Question:

I’ve been on Prozac, Paxil, Zoloft and Trazodone. The Trazodone is nice in that it helps me sleep at night(that is mainly what I use it for. The Zoloft did not work for me, either. The only thing I recall working is the Prozac. I am back on it as of today. I will see how it works this time. :-)

Response:

I haven’t noticed much in the way of side effects besides being sleepy the first couple weeks.

Aha… so I’m not the only one… hehe… Liah who is sleeping way too much

Response:

Of all the SSRI type meds, I liked Paxil the best. Im kinda aggressive (not violent) and it takes the edge off better than zac or loft. Kinda costs more tho….. Good luck 2u, Kev – Hide quoted text — Show quoted text – I switched from Zoloft to Prozac for the same reason. This is my second go round with Prozac. I haven’t noticed much in the way of side effects besides being sleepy the first couple weeks. It’s gotten me out of the depths, but I’m not really *happy* per se, so I think it’s gonna take therapy to get me the rest of the way. Melissa — Hand over the chocolate, and no one gets hurt.

Response:

I switched from Zoloft to Prozac for the same reason. This is my second go round with Prozac. I haven’t noticed much in the way of side effects besides being sleepy the first couple weeks. It’s gotten me out of the depths, but I’m not really *happy* per se, so I think it’s gonna take therapy to get me the rest of the way. Melissa — Hand over the chocolate, and no one gets hurt.

Response:

trina, different ADs work differently in different people, i was on zoloft but had no success, same thing with prozac, effexor, and now i’m trying aropax again. Because they have different effects on different people it makes it difficult to try to recommend any other AD’s, all i can rwally say is keep trying until you find something you feel works for you. Good Luck! – Hide quoted text — Show quoted text – i started taking zoloft back in april. i think it helped my depression for a bit, but i don’t think it does anymore. lately i’ve been getting more and more depressed, and i realized that this could simply be due to the fact that the weather is changing and all, but it doesn’t feel like just that. i’ve been having a lot of problems dealing with life in the real world lately, avoiding obligations, calling in sick to work because i can’t get out of bed, etc. i’ve been starting to wonder if zoloft ever really worked for me, or if the "up" (not that it was a very high up) i felt might have just been a placebo effect because i was finally doing something about my depression. has anyone else had this same experience? if so, what did you do about it? i’ve been thinking about asking my doctor (just a GP, i don’t have a pdoc) to prescribe me some new meds. i don’t know that much about ADs though. what i’ve learned about drugs other than SSRIs kinda scares me (possibly unfounded), so i would kind of like to stick within the SSRI group. i’ve been told that prozac has a bit more of a "kick" than zoloft, is that true? has anyone here ever switched from zoloft to prozac, and if so, what are the differences in positive effect, side effects, etc.? also, any strong recommendations for other drugs? i would really appreciate some help with this, because i’ve been really struggling. i’m afraid i’m going to get really bad again, and won’t be able to handle it. i need to be better, because i can’t afford to be bad right now. thanks in advance, trina take "nospam" out of the reply address to e-mail.

Response:

i started taking zoloft back in april. i think it helped my depression for a bit, but i don’t think it does anymore. lately i’ve been getting more and more depressed, and i realized that this could simply be due to the fact that the weather is changing and all, but it doesn’t feel like just that. i’ve been having a lot of problems dealing with life in the real world lately, avoiding obligations, calling in sick to work because i can’t get out of bed, etc. i’ve been starting to wonder if zoloft ever really worked for me, or if the "up" (not that it was a very high up) i felt might have just been a placebo effect because i was finally doing something about my depression. has anyone else had this same experience? if so, what did you do about it? i’ve been thinking about asking my doctor (just a GP, i don’t have a pdoc) to prescribe me some new meds. i don’t know that much about ADs though. what i’ve learned about drugs other than SSRIs kinda scares me (possibly unfounded), so i would kind of like to stick within the SSRI group. i’ve been told that prozac has a bit more of a "kick" than zoloft, is that true? has anyone here ever switched from zoloft to prozac, and if so, what are the differences in positive effect, side effects, etc.? also, any strong recommendations for other drugs? i would really appreciate some help with this, because i’ve been really struggling. i’m afraid i’m going to get really bad again, and won’t be able to handle it. i need to be better, because i can’t afford to be bad right now. thanks in advance, trina take "nospam" out of the reply address to e-mail.

Response:

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Category: Prozac Effexor
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Prescription Medication Knowledge Base » Effexor Xr With » Anyone tried Meridia?

Anyone tried Meridia?

Question:

– Hide quoted text — Show quoted text – The feedback here is that it works for some people, doesn’t work for a lot of others. As I understand it, Meridia is not at all chemically similar to phen/fen and does not work on the system in a similar manner — the only similarity is that it is prescribed for the same condition, obesity. As for so-called "dangerous side effects," that should be "the suspicion that there might be dangerous side effects," not so far proven in any of the studies, but still generating enormous lawsuits. What there are already lawsuits going after Meridia, too? Tell me you’re kidding, please…

When the ambulance chasers salivating with greed invaded this newsgroup right after the recall, they were looking for people to join class actions for either of the two drugs. Inasmuch as I know someone who joined such a suit "just in case" — even though she had experienced no harm from the phen/fen — I can only assume that they got some Redux users, as well. I don’t know that any suits have been filed, but I know they were trying to get them started. — Truly Donovan reply to truly at lunemere dot com

Response:

- Hide quoted text — Show quoted text – The feedback here is that it works for some people, doesn’t work for a lot of others. As I understand it, Meridia is not at all chemically similar to phen/fen and does not work on the system in a similar manner — the only similarity is that it is prescribed for the same condition, obesity. As for so-called "dangerous side effects," that should be "the suspicion that there might be dangerous side effects," not so far proven in any of the studies, but still generating enormous lawsuits. What there are already lawsuits going after Meridia, too? Tell me you’re kidding, please… When the ambulance chasers salivating with greed invaded this newsgroup right after the recall, they were looking for people to join class actions for either of the two drugs. Inasmuch as I know someone who joined such a suit "just in case" — even though she had experienced no harm from the phen/fen — I can only assume that they got some Redux users, as well. I don’t know that any suits have been filed, but I know they were trying to get them started.

Oh, so when you were talking about "dangerous side effects" and "enormous lawsuits" above you were talking about fen/Redux, and not Meridia, right? That wasn’t clear to me. As far as I know, the statute of limitations for filing class action suits on behalf of fen/phen "victims" has expired and I know of none that have been filed on time. As to invididual suits, none of them came out in favor of the so-called "victim". To email me, remove the X

Response:

My doctor has suggested I try the prescription Meridia. It is similar to Phen-Fen but without the dangerous side effects. It works at stabilizing metabolism and reducing hunger. His current users lose an average of 4 to 10 lbs. per month depending on if they exercise and diet in addtion to the pills.

I was on it for 6 weeks. Didn’t work worth a damn–in fact, I think I gained a few pounds. My doctor switched me to phentermine, and I’ve been losing approx 10 pounds/month–35 now since May 1. — Steve Dyer

Response:

My doctor has suggested I try the prescription Meridia.

My doctor put me on Meridia 4 weeks ago and so far so good! I’ve lost 15 pounds and found that I feel full without a lot of cravings. I’m also on 1000 calorie diet and trying to exercise on my treadmill 3-4 times a week. I’ve been on 10mg but I’ve been feeling hungry and cravings the last few days so they’ve upped my prescription to 15mg which I’ll fill tomorrow. My major side effect was dry mouth, which has abated somewhat. I had a killer headache on the second day but none since. My blood pressure and heart rate are monitored regularly and haven’t shown any change, but I have always had low blood pressure so I wasn’t too worried about that possibility. I was never on Fen/Phen so I can’t compare Meridia to it. It is definitely nice to feel full without overeating for a change!! Kim 245/230/135 ComputerSmiths Consulting, Inc. www.compusmiths.com — Crafting Solutions for Computers

Response:

If you give Meridia a try, I recommend having a complete physical before starting and then monitoring your blood pressure and heart rate carefully – perhaps even daily at first! While individual responses vary, mine was not so good. It suppressed my appetite to almost zero (positive!) but heart rate and blood pressure went up a lot. I felt great for the first two days. Then on day three of taking the medication I became so nauseous and light-headed I almost passed out at work and required medical attention. I was taking the recommended starting dose of 10 mg/day. It took three days for my heart rate to return to normal. The effect on my appetite was so dramatic that I am considering trying again at 5 mg dosage or taking 10 mg only every other day or two. — Katie– I never believe anything until it’s been officially denied. – Hide quoted text — Show quoted text – My doctor has suggested I try the prescription Meridia. It is similar to Phen-Fen but without the dangerous side effects. It works at stabilizing metabolism and reducing hunger. His current users lose an average of 4 to 10 lbs. per month depending on if they exercise and diet in addtion to the pills.

Response:

The feedback here is that it works for some people, doesn’t work for a lot of others. As I understand it, Meridia is not at all chemically similar to phen/fen and does not work on the system in a similar manner — the only similarity is that it is prescribed for the same condition, obesity. As for so-called "dangerous side effects," that should be "the suspicion that there might be dangerous side effects," not so far proven in any of the studies, but still generating enormous lawsuits. — Truly Donovan reply to truly at lunemere dot com

Response:

What there are already lawsuits going after Meridia, too? Tell me you’re kidding, please…

Response:

I just went off Meridia after two non-effective months. I had killer PMS while on it too– carbo/salt cravings you wouldn’t believe. My dr attributes this to the weight I already lost– says that my hormones are just working much better now. Well gee thanks hormones. I’ve gained back 7 since they took away the Fen…. and somedays I feel like I’m tottering on the edge of gaining it all back – M.

Response:

As I understand it, Meridia is not at all chemically similar to phen/fen and does not work on the system in a similar manner Meridia (sibutramine) is a chemically a phenethylamine, just like Dexedrine, phentermine, fenfluramine, and Redux. Pharmacologically, it does not work the same way as those drugs; it’s mechanism is almost identical to that of the antidepressant drug Effexor (venlafaxine). Effexor is useless for weight loss (except as an unwanted side effect in a small number of people) and so is Meridia.

Response:

My doctor has suggested I try the prescription Meridia. It is similar to Phen-Fen but without the dangerous side effects. There’s one other difference between Meridia and phen/fen: phen/fen worked, and Meridia doesn’t. Meridia wins on one count, however: it’s more expensive than phen/fen was. I predict that Meridia will be gone within a year, not because of some terrible side effect that’s discovered, but because it simply won’t sell. It doesn’t work any better than placebo.

Response:

Meridia (sibutramine) is a chemically a phenethylamine, just like Dexedrine, phentermine, fenfluramine, and Redux. Pharmacologically, it does not work the same way as those drugs; it’s mechanism is almost identical to that of the antidepressant drug Effexor (venlafaxine). Effexor is useless for weight loss (except as an unwanted side effect in a small number of people) and so is Meridia.

Although I experienced a minor decrease in appetite while taking prozac, from what I understand more people gain weight on it than actually lose weight. Do you know whether Effexor has the same reputation for causing weight gain? If not, perhaps it would be worth a try to see if I’m one of that small number who loses. AB

Response:

I’ve never heard of weight gain with Effexor. A certain percentage of people experience weight loss with it, but the weight loss isn’t very significant. I’ve been wondering lately whether Effexor combined with phentermine might be useful. You could end up with overstimulation, at least theoretically, but it seems like they would potentiate one another. A few years ago, Lilly was going to try to get Prozac indicated for obesity. It does seem to suppress appetite in some people, but the effect is inconsistent, and even when it works, it’s not very dramatic. The world is still waiting for a really effective pharmacotherapy for obesity. Phen/fen really seemed to have been it for a certain number of people, but I wasn’t one of them. – Hide quoted text — Show quoted text – Meridia (sibutramine) is a chemically a phenethylamine, just like Dexedrine, phentermine, fenfluramine, and Redux. Pharmacologically, it does not work the same way as those drugs; it’s mechanism is almost identical to that of the antidepressant drug Effexor (venlafaxine). Effexor is useless for weight loss (except as an unwanted side effect in a small number of people) and so is Meridia. Although I experienced a minor decrease in appetite while taking prozac, from what I understand more people gain weight on it than actually lose weight. Do you know whether Effexor has the same reputation for causing weight gain? If not, perhaps it would be worth a try to see if I’m one of that small number who loses. AB

Response:

: I’ve just begun doing web searches for info on Effexor. Having found : anything addressing the combination of the Effexor and Phen yet. Anyone : have any info/ideas? : I haven’t found anything anywhere specifically addressing the combination. : A good place to look for information on stuff like this is MedLine, which : you can get to at http://www.ncbi.nlm.nih.gov/PubMed/ Okay, thanks. : The chemical name of Effexor is venlafaxine (MedLine refers to drugs by : their chemical names). : I’ve been searching for information on the combination of venlafaxine and : phentermine lately. If I find anything, I’ll be sure to post it. : One possible concern about this combo would definitely be blood pressure. : Effexor, like Meridia (they’re very similar drugs) can cause a sustained : increase in blood pressure. Phentermine can increase blood pressure too, : and should be used with caution where there’s already high blood pressure. : Of course, obesity has its own health risks, and on the balance, the risks : of the drug-induced hypertension may be offset by the benefits of weight : loss. At least, this was the argument that Knoll (makers of Meridia) made : to get their product on the market. Yes, I’m a little worried about this doctor’s attention to health-related side effects – I realized after I left his office that he hadn’t even taken my blood pressure! I’ve been having my blood pressure read every month or so throughout all med changes (phen/fen, phen/pro, etc.), and it’s always been around 110/70, so I’m not terribly worried, but obviously I’m going to have to be the one staying on top of what side effects to be worried about. It’s hard finding a doc who is informed about the brain/body aspects of obesity, knows the meds, the possible side effects, is open-minded (doesn’t prescribe diet/exercise exclusively), knows how to listen, and is a good overall doctor… I just recently got med insurance after doing without (stupid, I know; I kept _meaning_ to get an individual plan, but the cost was offputting) for almost 2 years. So I’m shopping. Julie

Response:

Placebos work for some people; so does Meridia. If it has to be expensive to have that effect, so be it. — Truly Donovan reply to truly at lunemere dot com

Response:

I’ve just begun doing web searches for info on Effexor. Having found anything addressing the combination of the Effexor and Phen yet. Anyone have any info/ideas? I haven’t found anything anywhere specifically addressing the combination. A good place to look for information on stuff like this is MedLine, which you can get to at http://www.ncbi.nlm.nih.gov/PubMed/ The chemical name of Effexor is venlafaxine (MedLine refers to drugs by their chemical names). I’ve been searching for information on the combination of venlafaxine and phentermine lately. If I find anything, I’ll be sure to post it. One possible concern about this combo would definitely be blood pressure. Effexor, like Meridia (they’re very similar drugs) can cause a sustained increase in blood pressure. Phentermine can increase blood pressure too, and should be used with caution where there’s already high blood pressure. Of course, obesity has its own health risks, and on the balance, the risks of the drug-induced hypertension may be offset by the benefits of weight loss. At least, this was the argument that Knoll (makers of Meridia) made to get their product on the market.

Response:

: I’ve never heard of weight gain with Effexor. A certain percentage of : people experience weight loss with it, but the weight loss isn’t very : significant. I’ve been wondering lately whether Effexor combined with : phentermine might be useful. You could end up with overstimulation, at : least theoretically, but it seems like they would potentiate one another. Funny you should mention this. Just yesterday I saw a new doctor, who seems to be developing a subspecialty in treating weight. I told him my history – success with phen/fen, no success with Meridia or phen/pro or phen/wellbutrin, maintaining with difficulty on phen and 5-HTP. He said that the only combo he’s been having success with has been phentermine and Effexor, so I’m starting that today. Currently 30 mgs phentermine, 37.5 Effexor. I’ve just begun doing web searches for info on Effexor. Having found anything addressing the combination of the Effexor and Phen yet. Anyone have any info/ideas? Julie

Response:

I have been getting killer headaches when I take 15 mg, but not when I take 10 mg. It’s happening consistantly enough that I think it’s related to the dosage. Otherwise, I’ve been really happy with it. – Hide quoted text — Show quoted text – My doctor has suggested I try the prescription Meridia. My doctor put me on Meridia 4 weeks ago and so far so good! I’ve lost 15 pounds and found that I feel full without a lot of cravings. I’m also on 1000 calorie diet and trying to exercise on my treadmill 3-4 times a week. I’ve been on 10mg but I’ve been feeling hungry and cravings the last few days so they’ve upped my prescription to 15mg which I’ll fill tomorrow. My major side effect was dry mouth, which has abated somewhat. I had a killer headache on the second day but none since. My blood pressure and heart rate are monitored regularly and haven’t shown any change, but I have always had low blood pressure so I wasn’t too worried about that possibility. I was never on Fen/Phen so I can’t compare Meridia to it. It is definitely nice to feel full without overeating for a change!! Kim 245/230/135 ComputerSmiths Consulting, Inc. www.compusmiths.com — Crafting Solutions for Computers

Response:

Do you know whether Effexor has the same reputation for causing weight gain? If not, perhaps it would be worth a try to see if I’m one of that small number who loses. AB

I gained weiht on both drugs, not as much on Prozac, but quite a bit on Effexor, say 20 pounds over a 6 month period. JaneG

Response:

If they exercise and diet WITHOUT the pills they’ll lose 4 lbs a month. It doesn’t sound like it’s worth it.

Response:

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Prescription Medication Knowledge Base » Prozac Effexor » Sexual Desire Problems

Sexual Desire Problems

Question:

Brett- This kind of problem always appeared for me (as for about a million others) if an SSRI was involved at a normally therapeutic dosage. (I’m including Welbutrin here even though I think its action is primarily dopamine-related, but not sure.)

higher doses-but not ejac.(my studied opinion based on reading. – Hide quoted text — Show quoted text – When I was properly diagnosed as bipolar I was taken off all SSRIs and put on tegretol which has no such negative effects on plumbing. Sometime later a very small, "subtherapeutic" dose of effexor was added to the tegretol/klonopin combo. It seemed to have positive effect on mood in spite of how small the dose was, and it had no sexual side effects at all. If you are bipolar, why don’t you discuss with a psychopharmacologist the possibility of relying less on SSRIs? Negative sexual side effects are serious side effects in my opinion, in spite of the triviality with which some people may view them. Shukoku I hate to beat on a dead horse and am sure that this subject has been brought up many times, but I needto bring it up again. I’m on a combo of depekote, wellbutrin, klonopin and prozac and am suffering from serious sexual disfunction. Not to get into too much detail, but I can do all but ejaculate. I was thinking that maybe "Yohimba" might help…. Anyone tried it? How about that new drug on the market for impotence?? It would just add one more pill to the many we already take daily, but to have a sex live, it would be worth it. I’ve pretty much come to terms with the fact that this subject will always be a problem for me and a delicate one for my partner as she feels guilty that she cannot "please" me as she would like to. I would rather live a "normal" life and give up a portion of my sex life… But will constantly look for a solution. Anyone tried either method??? what is an SSRI? thanks, tom arnall fort washington, md usa

Response:

Well I can pretty well tell you which drug is the major *culprit* in

Don’t be too sure that the problem is solely from Klonopin. Prozac is also known to cause sexual dysfunction, including inorgasmia. I am not sure, but that may be a general problem with SSRI’s. This problem should be discussed with your pdoc. Don’t add any "natural" remedies without checking with the doctor first. It can be dangerous to mix over-the-counter meds with prescription drugs. Good luck.

Response:

Brett.. just read your post.. Check this out.. it’s becoming the TOC in SSRI-induced sexual dysfunction.. it’s a great cognitive enhancer too, but make sure you get a quality standardized extract. Nature’s Way and Eclectic Institute in Oregon have good products, or you can call L & H Vitamins toll free in NYC.. E-mail me if you want tel #’s. http://www.publinet.it/pol/pharmol/gingko.htm (gingko biloba)

Response:

I find Zoloft is just as bad, with a total kill of the sex drive. – Hide quoted text — Show quoted text – Well I can pretty well tell you which drug is the major *culprit* in Don’t be too sure that the problem is solely from Klonopin. Prozac is also known to cause sexual dysfunction, including inorgasmia. I am not sure, but that may be a general problem with SSRI’s. This problem should be discussed with your pdoc. Don’t add any "natural" remedies without checking with the doctor first. It can be dangerous to mix over-the-counter meds with prescription drugs. Good luck.

Response:

- Hide quoted text — Show quoted text – Brett- This kind of problem always appeared for me (as for about a million others) if an SSRI was involved at a normally therapeutic dosage. (I’m including Welbutrin here even though I think its action is primarily dopamine-related, but not sure.) When I was properly diagnosed as bipolar I was taken off all SSRIs and put on tegretol which has no such negative effects on plumbing. Sometime later a very small, "subtherapeutic" dose of effexor was added to the tegretol/klonopin combo. It seemed to have positive effect on mood in spite of how small the dose was, and it had no sexual side effects at all. If you are bipolar, why don’t you discuss with a psychopharmacologist the possibility of relying less on SSRIs? Negative sexual side effects are serious side effects in my opinion, in spite of the triviality with which some people may view them. Shukoku I hate to beat on a dead horse and am sure that this subject has been brought up many times, but I needto bring it up again. I’m on a combo of depekote, wellbutrin, klonopin and prozac and am suffering from serious sexual disfunction. Not to get into too much detail, but I can do all but ejaculate. I was thinking that maybe "Yohimba" might help…. Anyone tried it? How about that new drug on the market for impotence?? It would just add one more pill to the many we already take daily, but to have a sex live, it would be worth it. I’ve pretty much come to terms with the fact that this subject will always be a problem for me and a delicate one for my partner as she feels guilty that she cannot "please" me as she would like to. I would rather live a "normal" life and give up a portion of my sex life… But will constantly look for a solution. Anyone tried either method???

what is an SSRI? thanks, tom arnall fort washington, md usa

Response:

You asked what a SSRI is ? It’s a Serotonin-Specific Reuptake Inhibitor. It means that the Serotonin Reuptake site is blocked and serotonin stays in the synaptic cleft (and seeps out, where it might activate pre-synaptic receptors) where serotonin activates the post-synaptic receptors. In other words. a SSRI is a material that has potenial anti-depressant, stabilizing and anti-anxiety properties, because the brains’ Serotonin system is stabilized (mostly at a higher level of activity). a SSRI, like prozac (fluoxetine), paroxetil/Seroxat (paroxetine) will, because it’s serotonin-specific, therefore exhibit very rarely many side effects. Whether they work better as the classical tricyclics still remains to be seen, but the apparent lack of side effects is VERY NICE! GREETINGS and Keep Sailing The Seas Of High Hopes ! Bas DE DIGITALE STAD

Response:

DE DIGITALE STAD Op Wed, 27 May 1998, Chip schreef: I hate to beat on a dead horse and am sure that this subject has been brought up many times, but I needto bring it up again. I’m on a combo of depekote, wellbutrin, klonopin and prozac and am suffering from serious sexual disfunction. Not to get into too much detail, but I can do all but ejaculate. I was thinking that maybe "Yohimba" might help…. Anyone tried it? How about that new drug on the market for impotence?? It would just add one more pill to the many we already take daily, but to have a sex live, it would be worth it.

Taking Yohimbe (That’s the dutch name of the inner bark of an african tree) in combination with Prozac is a definite No-NO! Yohimbe containse Yohimbine, which is beside a vasodilator of the genitals (Due to adrenergic

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Prescription Medication Knowledge Base » Effexor Dose » Lamotrigine (Lamictal)

Lamotrigine (Lamictal)

Question:

Thanks for the information David. I suggest you visit this site for more information on Lamictal (lamotrigine) Depression Central: http://www.psycom.net/depression.central.html There’s some great infomration there! Juliet Ring the bells that still can ring Forget your perfect offering. There is a crack in everything. That’s how the light gets in. – Leonard Cohen, "Athem"-

Response:

Hi Surfs Edge/ Juliet: I’ve been on lamactal for about 3 months. I am a very rapid cycler (I have cycled three time a day.), however lamictal was help to stop my mania. The only real problem that I have is that I am resistant to these meds. Over the last three years I have been on over a 100 different combinations of meds. One combination lasted nine months until it broke down (frustrating). the lamictal has work very well for me until this week. I was up to 300mg per day plus 300mg of lithium. I was previously on 1200 mg of lithium until I started lamictal. I have not experienced any side effect from lamictal. But, as you were told in a previous letter, each of us is unique and reacts differently to various meds. Good luck to you. Arne – Hide quoted text — Show quoted text – Has anyone had first hand expierence with lamotrigine (lamictal)? I am considering taking this med and am trying to learn more about it. I have found about the stats, etc but haven’t spoken to someone who takes this med. Any information would be appreciated. Thanks. Juliet Ring the bells that still can ring Forget your perfect offering. There is a crack in everything. That’s how the light gets in. – Leonard Cohen, "Athem"-

Response:

Hi, I’ve been on Lamictal for a month and a half with no problems and some benefit, see my post in alt.support.depression.manic, which just goes to show what sucks about this illness .. The only way to find out how you are going to react to a medication is to take it. Rapid cyclers seem to be particularly problematic. In my case over the summer I was on Paxil an SSRI anti depressant similar to Prozac. It made me depressed and sleepy. When I went off it I went slightly manic for several weeks. Go figure. Try to be philosophical as you experience the adventure of taking a new medication(See my posting to MoiraArwen Re Depakote in alt support depression.manic) In any case hang in there everyone. David – Hide quoted text — Show quoted text – Has anyone had first hand expierence with lamotrigine (lamictal)? I am i just switched off it. in my experience: good antimanic. supposedly has AD effects, but i went into a long depression on it, even though i’m usually a rapid-cycler. made me very drowsy. required me doubling my effexor dose, and i had to add atenolol for the tremors. and it’s not coated, so it tastes icky, if anyone but me cares. brooke — the further i get from the things that i care about, the less i care about how much further away i get (cure)

Response:

An FAQ on lamotrigine (Lamictal) may be found at: http://www.psycom.net/depression.central.lamotrigine.html Best regards . . . Ivan

: Has anyone had first hand expierence with lamotrigine (lamictal)? I am : considering taking this med and am trying to learn more about it. I have : found about the stats, etc but haven’t spoken to someone who takes this : med. Any information would be appreciated. Thanks. : Juliet : Ring the bells that still can ring : Forget your perfect offering. : There is a crack in everything. : That’s how the light gets in. : – Leonard Cohen, "Athem"- — — \\ || Ivan Goldberg, MD ~ || || V: 212 876 7800 / 1346 Lexington Ave NYC 10128 / F: 212 737 0473 || || http://www.psycom.net/depression.central.html || || http://www.psycom.net/ijppp.html ||

Response:

Has anyone had first hand expierence with lamotrigine (lamictal)? I am considering taking this med and am trying to learn more about it. I have found about the stats, etc but haven’t spoken to someone who takes this med. Any information would be appreciated. Thanks. Juliet Ring the bells that still can ring Forget your perfect offering. There is a crack in everything. That’s how the light gets in. – Leonard Cohen, "Athem"-

Response:

Greetings Juliet: Below is some information that I found about Lamictal on the www. I’ve been taking it for 6 weeks so far. I’ve gradually been increasing the dose. I am up to 37.5 mg/day along with 500 mg/day Depakote. I think the lamictal is helping me. It is making a depression that I am going through now less severe than it would be otherwise. I am at a rather low dose as yet. People typically take 3 times the dose that I am taking. The only side effect that I have had is a slight headache for the first day when I increase the dose each time. I started taking only a half a 25mg pill every other day. I found out about this medication on my own via the internet and my Dr. got more information from the drug comany. It seems to be safe and has been used outside of the us by a lot of people. Anti depressants have never helped me. Lithium has never helped me. Depakote seems to make my cycles less extreme but mainly helps with mania. I’ve used that for several years. I am guardedly optimistic about Lamictal. If you have other information besides what I’ve attached and what is in the PDR, I’d be interested in hearing about it. If there is anything else you’d like to know please feel free to ask. In any case hang in there, David David Vogel Hackensack NJ Online Coverage from the 149th Annual Meeting of the American Psychiatric Association Lamotrigine in Treatment-Refractory Bipolar Disorder Robert M. Smith, MD Lamotrigine was effective in both phases of bipolar disorder in an open trial, with its most significant role anticipated for treatment of the depressed phase. Joseph Calabrese, MD, of Case Western Reserve Medical Center reported on the first 6 months of a 12-month, multicenter, open inital study of lamotrigine in treatment-resistant or -intolerant bipolar patients. Lamotrigine is an anticonvulsant derived from an antimalarial agent which has now been used in over 200,000 patients. Initial case reports in patients taking the drug showed it was effective in rapid-cycling patients with severe, refractory depression. It is well known that the depressed phase of bipolar disorder is particularly difficult to treat. The study reported on by Dr. Calabrese included 218 patients with bipolar disorder I or II, in any phase except euthymic; patients with epilepsy or active substance abuse were excluded. Positive response to lamotrigine was seen in 64% of depressed patients, and 76% of hypomanic/manic/mixed patients, as reflected in standardized measures. The study included some patients who received lamotrigine alone, and others who had a combination of antimanic agent(s) plus lamotrigine. The most common side effect and reason for discontinuing the drug was development of a rash. Lamotrigine was generally well tolerated and the results suggest efficacy in both the manic and depressed phases in bipolar disorder. Dr. Calabrese stated that the guidelines listed in the PDR may be used as a reference for dosage and estimated that the average required dose will be approximately 150mg. The drug must be titrated slowly, especially if given concurrently with medications that inhibit hepatic metabolism, such as valproate. A double-blind study is currently being conducted. Robert M. Smith, MD Robert M. Smith, MD is Attending Psychiatrist at St. Lukes/Roosevelt Hospital Outpatient Psychiatry Clinic; Candidate at The New York Psychoanalytic Institute; and Medical Director of the Villa Outpatient Substance Abuse Center. Dr. Smith was Chief Resident in Psychiatry from 1992 to 1993 at NYU Medical Center. http://www.medscape.com Antidepressants that once induced mood-cycling do not do so when administered along with lamotragine (Lamictal). It seems that this newly released (in the USA) anticonvulsant will play at least as large a role as valproate in the treatment of pholks with bipolar mood disorders. See also: general info on lamotrigine and its use in seizure disorders. I have found lamotrigine often to be effective in the treatment of patients: with rapid cycling bipolar disorder with hard-to-treat mixed states with depression in whom antidepressants cause mania or cycling Lamotrigine is tolerated best when introduced slowly. A rash that may necessitate discontinuation is more likely to develop in patients started on too high a dose or in those patients in whom the dose is increased too rapidly. There are some pharmacokinetic interactions of lamotrigine that should be kept in mind. Carbamazepine levels are increased by lamotrigine, and valproate levels are decreased somewhat by lamotrigine. Enzyme inducers such as carbamazepine decrease the t-1/2 of lamotrigine to the point where it should be administered q12h rather than q.o.d. In a patient not taking carbamazepine I usually initiate tx with 25 mg h.s. and increase the dose by 25 mg per day per week until a dose of 100 mg h.s. is reached. If a response is not seen after one week at this dose, I then increase the dose to 200 mg h.s. With a few patients I have had to go higher. Most impressive have been the results with rapidly cycling bipolar individuals who have not responded to valproate and/or carbamazepine. Also, the protection against antidepressant-induced cycling and mania has been very useful. I have also had good experiences using lamotrigine to treat the mood lability of so called "borderline" patients. There are no double-blind placebo-controlled studies to confirm the observations above. Charles Bowden has reported worthwhile preliminary results with lamotragine in bipolar patients, N = about 50, not published yet… Manufacturer reportedly somewhat concerned about high incidence of rashes and isn’t sure if they are comfortable investigating it for new use until there is more post-marketing data. At 07:30 AM 4/28/96 -0400,

You mention that you begin with a dose of 25 mg h.s. on patients not taking carbamazepine. How about patients on valproate? The PDR suggests that one begins with a dose of 25 mg every other day for two weeks. Other questions: Do your patients end up only on lamotrigine? How frequently do they end up on a combination of lamotrigine and carbamazepine? With patients on valproate I begin with 1/2 of a 25 mg tablet at bedtime and slowly increase the dose from there. As I see few people on carbamazepine these days, I have few who end up on the combination of carbamazepine + lamotrigine. Those who are asked for a reference regarding the innovative use of lamotrigine with patients who have treatment-resistant mood disorders may find Lamotrigine in Treatment-Refractory Bipolar Disorder useful. (EDT) "Start low and go slow" to minimize the risk of rash or other significant adverse events. – Hide quoted text — Show quoted text -Has anyone had first hand expierence with lamotrigine (lamictal)? I am considering taking this med and am trying to learn more about it. I have found about the stats, etc but haven’t spoken to someone who takes this med. Any information would be appreciated. Thanks. Juliet *** Ring the bells that still can ring Forget your perfect offering. There is a crack in everything. That’s how the light gets in. - Leonard Cohen, "Athem"- ***

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